Base membranes are thin extracellular matrices that cells adhere to and grow on in vivo. PepGel PGmatrix-CDX/PDX (PGmatrix-CDX) is a protein based solubilized base membrane synthesized from commonly used amino acids and minerals. The amino acids include Arginine, Aspartate, Glycine, Isoleucine, Leucine, Lysine, Phenylalanine, Proline, Serine, and Valine. PGmatrix-CDX is compatible with various adhesion proteins and cell growth factors, including but not limited to laminin, collagens, VE-growth factor, fibroblast growth factor, and other growth factors. PGmatrix-CDX is a powerful reagent for the packaging and delivery of various cell types (cancer cells, stem cells, T-cells, etc) in vivo for xenograft animal models or therapeutic trials. PGmatrix-CDX provides many advantages that customers prefer such as:
- No more icing: all operational and growth procedures are done at room temperature or 37°C in neutral pH. Cells no longer suffer acidic or chilled conditions.
- Easy procedures: cells are easily encapsulated and injected into a target location in vivo. From there, cells can grow to form tumors using the matrix as support, after which the matrix easily degrades into absorbable amino acids.
- Well-defined system: the gel matrix has defined components.
- Biocompatible: the gmatrix is highly biocompatible with biological environments, avoiding infections while accurately reflecting the cell microenvironment.
A PGmatrix-CDX kit contains two solutions. The first is a PGmatrix trigger solution / PGmatrix trigger-HC solution: minerals, ions (sodium, calcium, potassium etc) and water. The second solution is a PGmatrix CDX solution / PGmatrix CDX-HC solution: synthetic proteins and water. (PG-CDX kit is for subcutaneous injection, PG-CDX-HC is for joint injection)