A perfect home for cells

The PGinVivo System utilizes the PepGel platform’s technology and is designed for easily encapsulating cells, antigens, viruses, drugs, and compounds, and then carrying them into the targeted locations in vivo. PGphArm is the home for cells; it is biocompatible, bio-absorbable, so-gel reversible by slight shearing force, nutrient diffusible, and easy to handle at room or body temperature. PGinVivo is the perfect tool for research with animals and for clinical applications for both animals and humans.

Advanced therapeutics and regenerative medicine for cancer and special genetic defect treatments have been severely limited by a lack of delivery tools to carry cells, genes, functional molecules, and compounds into the target location in vivo.

The challenge for cell delivery is that cells need a desirable initial “home” for the transplantation transition between in vitro and in vivo. Therefore, the cell carrier has to possess a 3D network matrix composed of fibrous matrix proteins that provide suitable structural integrity mimicking the natural extracellular matrix (ECM).

The PepGel PGinVivo System utilizes the PepGel platform’s technology and is designed for easily encapsulating cells or genes, drugs, and compounds, and then carrying them into the targeted locations in vivo. PGinVivo is the home for cells; it is biocompatible, bio-absorbable, injectable, so-gel reversible by slight shearing force, nutrient diffusible, and easy to handle at room or body temperatures. PGinVivo is the perfect tool for research with animals and clinical transplantations.

A regular PGmatrix research kit includes 6ml of 1% W/V PGmatrix nanofiber solution and 2ml of PGworks solution. Most cells grow well in PGmatrix concentrations of 0.2-0.5% W/V).

Case Studies

The PGinVivo product is completely biocompatible and bioabsorbable in vivo. PGinVivo (PGmatrix, h9e) has been used to deliver human stem cells and mouse stem cell into the mouse kidney area, and viruses into the tissue area of pigs.

In vivo delivery products

Relevant publications

  1. Self-Assembling Peptide Solution Accelerates Hemostasis. Advances in Wound Care, Advances in Wound Care, 2020.
  2. Controlled release of BSA-linked cisplatin through a PepGel self-assembling peptide nanofiber hydrogel scaffold, Amino Acids: The Forum for Amino Acid, Peptide and Protein Research, 29 May 2017.