PepGel™ PGmatrix™
Bioink Platform

PepGel™ PGmatrix™ Bioink – Versatile 3D Bioprinting Platform

PGmatrix™ Bioink harnesses PepGel’s advanced PGmatrix peptide-nanofiber technology to create physiologically relevant, well-defined, xeno-free 3D microenvironments. It enables precise bioprinting of living cells into both large-scale sheets and microscale constructs while preserving cellular health and function.

Core Technology

• Two-part system: Includes a vial of PGmatrix nanofiber solution and a vial of PGworks trigger solution.
• Native-like ECM: Forms a hydrogel that mimics the in-vivo ECM, supporting natural 3D cell growth and migration.
• Simple handling: All procedures run at room temperature or 37 °C under neutral pH and with no UV light or chemical crosslinkers required.
• Cellular functions: Supports the full range of cellular functions demonstrated with PGmatrix 3D Cells and PGmatrix Stem-X platforms.

• Direct bioprinting: Functions as a standalone bioink for creating large continuous sheets (up to ~2 mm thick) [1-2] or small-scale constructs (<64 mm³) by using inkjet or extrusion bioprinting, or manual pipetting [3-4].
• Hybrid constructs: PGmatrix Bioink can be mixed with high strength structural scaffolds, such as polyethylene glycol (PEG)-based bioink. PGmatrix reproduces the living cell environment while other bioinks supply mechanical strength for complex designs.
• Post-printing infusion: Infuse or perfuse PGmatrix Bioink with cells into pre-printed constructs or decellularized scaffolds.
• Custom combinations: Blend PGmatrix Bioink with other hydrogels or ECM proteins for specialized bioprinting applications.

• PG1006-010-BI, The highly selected bioink for improving cytocompatibility, it can be used alone for bioprinting large sheet (<3 mm thick), dome, 2 mm cube.
• PG1006-010-BI-C, Alternatively, it can be used as a composite bioink when combined with structural bioinks such as PEGDA, GelMA, HAMA for DLP bioprinting of highly complex constructs.