PepGel™ PGmatrix™ is the next-generation biomaterial inspired by the architecture and function of the human extracellular matrix (ECM), delivering physiologically relevant solutions for regenerative medicine and advanced life-science applications.
Traditional cell culture methods rely on flat, two-dimensional (2D) surfaces or force cells into artificial “3D” aggregates, creating mechanically constrained layers that compromise natural cell behavior and limit functional outcomes.
PGmatrix™ overcomes traditional cell culture limitations with a fully defined, animal-free platform that preserves the structural and functional integrity essential for cutting-edge regenerative medicine. Besides mechanical cues, our matrix incorporates a balanced array of built-in ECM ligands that engage cell-surface receptors, including integrins and cadherins, to provide the signaling cues that support cell survival, growth, expansion, and differentiation. This robust, physiologically relevant microenvironment enables breakthrough advances in drug discovery, disease modeling, stem-cell technologies, tissue regeneration, and offers exceptional biocompatibility for in vivo drug delivery.
A versatile portfolio of PGmatrix™ formulations is available and can be customized or recommended to match specific cell types or applications, such as epithelial, endothelial, stem, and cancer cells as summarized below.
PGmatrix products catalog #
PGmatrix 3D Cells
• PG1001-010-S, The most popular matrix for 3D cells, tumor organoids, organ organoids, iPSC (induced pluripotent stem cells), etc cultures.
• PG1002-010-INT2, The best matrix for endothelial cells, neural stem cells, MSCs (mesenchymal stem cells), epithelial cells, MDCKs, etc.
PGmatrix Stem-X
• PG1003-010-BF, The most popular matrix for 3D hiPSCs maintenance and expansion in embedded dome, sheet or suspension.
• PG1004-010-INT1, The best choice matrix for MSCs, brain organoids cultures, endothelial, epithelial cells.
• PG1005-010-Ncad, the best matrix for HSC (Hematopoietic stem cells), etc.
PGmatrix Bioink
• PG1006-010-BI, The highly selected bioink for improving cytocompatibility, it can be used alone for bioprinting large sheet (<3 mm thick), dome, 2 mm cube.
• PG1006-010-BI-C, Alternatively, it can be used as a composite bioink combining with structural bioinks such as PEGDA, GelMA, HAMA for DLP bioprinting into highly complex constructs.
PGmatrix Injection
• PG1007-010-IJ, The best option for in vivo delivery of cells, virus, antigens, exosomes, other biologics, as well as targeted proteins and peptides. It serves as an “adjuvant” for biological drugs to improve drug efficacy.
PepGel™ PGmatrix™ 3D Cells Platform Creates physiologically faithful cellular microenvironments for organoid culture, tissue regeneration, and cell expansion. Cells grow and self-organize into natural 3D colonies or organoids with true in-vivo fidelity.
Provides a stable and scalable 3D microenvironment to maintain and expand stem cells in a physiological manner, supporting robust differentiation into self-organized functional organoids, diverse somatic cell types, progenitor cells, and biologics for tissue regeneration and therapeutics.
Leverages PGmatrix’s tunable viscoelasticity and exceptional cytocompatibility to produce versatile bioinks suitable for inkjet, extrusion, digital-light, or microfluidic 3D bioprinting.
Facilitates minimally invasive delivery of therapeutic cells, growth factors, or drugs with high retention and biocompatibility.
Contact us today to learn more about Pepgel and how it can support your projects.
